Cell-based Models To Investigate Tau Aggregation
نویسندگان
چکیده
منابع مشابه
Cell-based Models To Investigate Tau Aggregation
Accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders including Alzheimer's disease. Tau is a neuron specific microtubule-associated protein that regulates microtubule stability, which is critical for axonal outgrowth and synaptic plasticity. In a pathological condition, tau dissociates from microtubules and forms insolu...
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The two histopathological hallmarks that characterize Alzheimer s disease (AD) are the extracellular amyloid plaques that are formed by b-amyloid fragments of the amyloid precursor protein (APP), and intracellular neurofibrillary tangles and neuropil threads, which consist of the microtubule-associated protein tau forming paired helical filaments with highly ordered structures, as recently corr...
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The pathological aggregation of tau into paired helical filaments is a hallmark of several neurodegenerative diseases, including Alzheimer's disease. We have generated cell models of tau aggregation in order to study mechanisms involving abnormal changes of tau. In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat...
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Tau pathology is characterized by intracellular aggregates of abnormally and hyperphosphorylated tau proteins. It is encountered in many neurodegenerative disorders, but also in aging. These neurodegenerative disorders are referred to as tauopathies. Comparative biochemistry of the tau aggregates shows that they differ in both tau isoform phosphorylation and content, which enables a molecular c...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2014
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2014.09.011